Is Panton–Valentine leucocidin (PVL) toxin associated with poor clinical outcomes in patients with community-acquired Staphylococcus aureus bacteraemia?
| العنوان: | Is Panton–Valentine leucocidin (PVL) toxin associated with poor clinical outcomes in patients with community-acquired Staphylococcus aureus bacteraemia? |
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| المؤلفون: | Emma McGuire, Claire Neill, Simon M. Collin, Hannah Higgins, Rebecca Guy, Mark Ganner, Juliana Coelho, Bruno Pichon, Russell Hope, Colin S. Brown |
| المصدر: | Journal of Medical Microbiology. 72 |
| بيانات النشر: | Microbiology Society, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Microbiology (medical), General Medicine, Microbiology |
| الوصف: | Introduction. Panton–Valentine leucocidin (PVL) toxin is a potential determinant of virulence associated with S. aureus infection. Gap Statement. The contribution of PVL to S. aureus pathogenicity remains unclear. Aim. To compare clinical outcomes in hospitalized patients with PVL-positive and PVL-negative community-acquired (CA) S. aureus bacteraemia. Methods. Three national datasets were combined to provide clinical and mortality data for patients with CA S. aureus blood culture isolates sent to the UK reference laboratory for PVL testing, August 2018 to August 2021. Multivariable logistic regression models were built for the effect of PVL positivity on 30 day all-cause mortality and 90 day readmission. Results. In 2191 cases of CA S. aureus bacteraemia, there was no association between PVL and mortality (adjusted odds ratio, aOR: 0·90, 95 % confidence interval, CI: 0·50–1·35, P=0·602) and no difference in median LOS (14 versus 15 days, P=0.169). PVL-positive cases had lower odds of readmission (aOR 0·74, CI 0·55–0.98, P=0·038). There was no evidence that MRSA status modified this effect (P=0·207). Conclusions. In patients with CA S. aureus bacteraemia PVL toxin detection was not associated with worse outcomes. |
| تدمد: | 1473-5644 0022-2615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d7523e8f9e0dee9b5b03ece42e97d904 https://doi.org/10.1099/jmm.0.001683 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........d7523e8f9e0dee9b5b03ece42e97d904 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14735644 00222615 |
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