Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives
| العنوان: | Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives |
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| المؤلفون: | Sunita Rattan, Vijay Kumar Sharma, Anup Barde |
| المصدر: | Asian Journal of Chemistry. 32:1101-1108 |
| بيانات النشر: | Asian Journal of Chemistry, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | chemistry.chemical_compound, Design synthesis, Pyrimidine, 010405 organic chemistry, medicine.drug_class, Chemistry, medicine, General Chemistry, Thiazolidinedione, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences |
| الوصف: | Novel thiazolidine-2,4-dione (TZD) based pyrimidine derivatives have been synthesized by Knoevenagel condensation reaction between thiazolidine-2,4-dione and amino pyrimidinyl aliphatic aldehydes followed by heterogeneous metal reduction. Synthetic strategy involved nucleophillic substitution of hydroxyl protected six membered aliphatic chain on 4,6-dichloropyrimidine followed by Suzuki coupling. This approach is regioselective, efficient and versatile for synthesis of such analogs |
| تدمد: | 0975-427X 0970-7077 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d780ad40912a4d2d16ee55ab89cf98c3 https://doi.org/10.14233/ajchem.2020.22565 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........d780ad40912a4d2d16ee55ab89cf98c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0975427X 09707077 |
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