A Trp in chi space
| العنوان: | A Trp in chi space |
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| المؤلفون: | Dorica Naylor, Simon A. Osborne, Mary Mckiernan, David C. Horwell |
| المصدر: | Letters in Peptide Science. 5:143-145 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Stereochemistry, Chemistry, Peptidomimetic, Pharmacology toxicology, Tryptophan, Space (commercial competition), Biochemistry |
| الوصف: | Our aim is to identify and synthesise a ‘family’ of tryptophan mimetics which thoroughly explore chi space and then incorporate them into selected ligands for biological receptors e.g. Tachykinin NK1. This project is considered important as only the ψ-φ angles have previously been explored; obtaining a greater understanding of the spacial orientation of the side chain in chi space (χ1-χ2) should prove invaluable to the future design of peptidomimetics. The amino acid tryptophan was selected as it has proved pivotal in many pharmaceutic drug programmes. |
| تدمد: | 1573-496X 0929-5666 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d8156db3de86d62a9a366544f0751793 https://doi.org/10.1007/bf02443457 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........d8156db3de86d62a9a366544f0751793 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1573496X 09295666 |
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