Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography
| العنوان: | Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography |
|---|---|
| المؤلفون: | Michele Ciccarelli, Valentina Errico, Massimo Roncalli, Edoardo Bottoni, Giuseppe Aranzulla, Enzo Angeli, G Chiesa, Giorgio Maria Ferraroli, Maurizio Infante, Anna Destro, Armando Santoro, Emanuele Voulaz, Fabio Romano Lutman, Raffaele Cavina, Pierina Navarria, Marta Scorsetti, Maurizio Chiarenza, Luca Toschi, Eliseo Passera, Giorgio Brambilla, Giovanna Finocchiaro, Arturo Chiti, Silvio Cavuto, Marco Alloisio |
| المصدر: | American Journal of Respiratory and Critical Care Medicine. 191:1166-1175 |
| بيانات النشر: | American Thoracic Society, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Incidence (epidemiology), Critical Care and Intensive Care Medicine, medicine.disease, Spiral computed tomography, law.invention, Randomized controlled trial, Interquartile range, law, medicine, National Lung Screening Trial, Radiology, Stage (cooking), Lung cancer, business, Lung cancer screening |
| الوصف: | Rationale: Screening for lung cancer with low-dose spiral computed tomography (LDCT) has been shown to reduce lung cancer mortality by 20% compared with screening with chest X-ray (CXR) in the National Lung Screening Trial, but uncertainty remains concerning the efficacy of LDCT screening in a community setting.Objectives: To explore the effect of LDCT screening on lung cancer mortality compared with no screening. Secondary endpoints included incidence, stage, and resectability rates.Methods: Male smokers of 20+ pack-years, aged 60 to 74 years, underwent a baseline CXR and sputum cytology examination and received five screening rounds with LDCT or a yearly clinical review only in a randomized fashion.Measurements and Main Results: A total of 1,264 subjects were enrolled in the LDCT arm and 1,186 in the control arm. Their median age was 64.0 years (interquartile range, 5), and median smoking exposure was 45.0 pack-years. The median follow-up was 8.35 years. One hundred four patients (8.23%) were diagnosed ... |
| تدمد: | 1535-4970 1073-449X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::da203ed438afee051cda74e7504dc160 https://doi.org/10.1164/rccm.201408-1475oc |
| رقم الأكسشن: | edsair.doi...........da203ed438afee051cda74e7504dc160 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354970 1073449X |
|---|