Transdermal Nicotine Delivery Systems: Multi-institutional Cooperative Bioequivalence Studies
| العنوان: | Transdermal Nicotine Delivery Systems: Multi-institutional Cooperative Bioequivalence Studies |
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| المؤلفون: | Kirti H. Valia, Te-Man Hsu, Senshang Lin, Chin-Ling Chueh, Yie W. Chien, Chau-Hsian Li, Jhili Wu, Wen-Chu Huang, Russel Rhei-Long Chen, Tsang-Shann Jiang |
| المصدر: | Drug Development and Industrial Pharmacy. 19:2765-2793 |
| بيانات النشر: | Informa UK Limited, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Pharmacology, integumentary system, business.industry, medicine.medical_treatment, Organic Chemistry, Pharmaceutical Science, Permeation, Bioequivalence, Dosage form, Bioavailability, Nicotine, Pharmacokinetics, Drug Discovery, Medicine, Smoking cessation, business, Transdermal, medicine.drug |
| الوصف: | Nicotine transdermal delivery systems (nicotine-TDSs) have been evaluated clinically and found to provide effective assistance to smokers in smoking cessation with minimal occurrence of withdrawal symptoms. However, substantial skin reactions have been reported with the four nicotine-TDSs marketed recently. To reduce the skin reactions, a new type of nicotine-TDS has been recently developed. In vitro skin permeation studies demonstrated that this nicotine-TDS yields a constant skin permeation profile with a rate of permeation across the human cadaver skin comparable to the steady-state permeation rates attained by Habitrol™ and Nicoderm® systems. Clinical studies completed in two ethnic groups have demonstrated that this newly-developed nicotine-TDS is clinically effective and has yielded minimal skin irritation. As part of technical transfer program, a clinical study was initiated in 18 non-obese non-smoking Taiwanese, using Latin-square design, to compare the systemic bioavailability and pharmac... |
| تدمد: | 1520-5762 0363-9045 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::dbb563eae727342a42279908c600125d https://doi.org/10.3109/03639049309050177 |
| رقم الأكسشن: | edsair.doi...........dbb563eae727342a42279908c600125d |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15205762 03639045 |
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