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Target Organ Specificity For N-Heterocyclic Aromatics

التفاصيل البيبلوغرافية
العنوان: Target Organ Specificity For N-Heterocyclic Aromatics
المؤلفون: Weiling Xue, Susan L. Fremont, Glenn Talaska, Tyrone Collins, Raymond Reilman, David Warshawsky, Marlene Jaeger, Patrick O'connor, Joanne Schneider
المصدر: Polycyclic Aromatic Compounds. 6:27-34
بيانات النشر: Informa UK Limited, 1994.
سنة النشر: 1994
مصطلحات موضوعية: Polymers and Plastics, Carbazole, Stereochemistry, Organic Chemistry, dBc, Metabolism, Carcinogenic process, Adduct, chemistry.chemical_compound, chemistry, Biochemistry, Acridine, Materials Chemistry, Carcinogen, Target organ
الوصف: N-Heterocyclic aromatics are environmental carcinogenic pollutants. Of these compounds, 7H-dibenzo[c,g]carbazole (DBC) is a liver and skin carcinogen in the mouse by topical application and a lung carcinogen by IP injection, whereas dibenz[a,j]acridine (DBA) is a skin carcinogen by topical application. Using 32P-postlabeling techniques, it was found that DBC-DNA adduct 6 is the major adduct in the liver, consistent with the metabolism of DBC to the 3-OH-DBC; adducts 2 and 3 are major adducts in the skin and adduct 3 is the major adduct in the lung. On the other hand, DBA adduction is apparent only in the skin and is consistent with the initial metabolism to DBA-3, 4-dihydrodiol. These data indicate that the adduct pattern, as well as the proximate metabolites, are target organ specific; these data will have an impact on the development of biomarkers of the carcinogenic process.
تدمد: 1563-5333
1040-6638
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ddd8854c09b7d8464363e46926c5954f
https://doi.org/10.1080/10406639408031164
رقم الأكسشن: edsair.doi...........ddd8854c09b7d8464363e46926c5954f
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15635333
10406638