055 Effects of Testosterone Treatment on Clitoral Haemodynamics in Women with Sexual Dysfunction
| العنوان: | 055 Effects of Testosterone Treatment on Clitoral Haemodynamics in Women with Sexual Dysfunction |
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| المؤلفون: | S. Cipriani, E. Maseroli, V. Di Stasi, I. Scavello, T. Todisco, G. Rastrelli, M. Fambrini, F. Sorbi, F. Petraglia, E.A. Jannini, M. Maggi, L. Vignozzi |
| المصدر: | The Journal of Sexual Medicine. 19:S146-S146 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Psychiatry and Mental health, Endocrinology, Reproductive Medicine, Urology, Endocrinology, Diabetes and Metabolism |
| الوصف: | Introduction Preclinical studies show that, in the clitoris, testosterone (T) is necessary to maintain a functional contractile and relaxant machinery, which represents the underlying mechanism of the peripheral arousal response. Although there is clinical evidence suggesting that T treatment significantly improves multiple domains of sexual functioning, the vascularization of clitoral tissue and its regulation by sex steroids are still under-investigated. Objective To explore the effects of 6-month systemic T administration on clitoral color Doppler ultrasound (CDU) parameters in women with female sexual dysfunction (FSD). Methods 81 women with FSD were retrospectively recruited. Data on CDU parameters at baseline and after 6 months with four different treatments were available and thus further longitudinally analyzed: local non-hormonal moisturizers (NH group), n=37; transdermal 2% T gel 300 mcg/day (T group), n=23; local estrogens (E group), n=12; combined therapy (T+E group), n=9. Patients underwent physical, laboratory, and genital CDU examinations at both visits and completed different validated questionnaires, including the Female Sexual Function Index (FSFI). Results At 6-month visit, T therapy significantly increased clitoral artery peak systolic velocity (PSV) when compared to both NH (p Conclusions In women complaining for FSD, systemic T administration, either alone or combined with local estrogens, was associated with a positive effect on clitoral blood flow and a clinical improvement in sexual function, showing a good safety profile. Disclosure Work supported by industry: no. |
| تدمد: | 1743-6109 1743-6095 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e04c74fe937c2c867ea0bf33e8e63867 https://doi.org/10.1016/j.jsxm.2022.03.589 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........e04c74fe937c2c867ea0bf33e8e63867 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17436109 17436095 |
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