Desymmetrization of a Propane-1,3-diol to Introduce the Quaternary Chiral Center of an AMG 176 Drug Substance Intermediate
| العنوان: | Desymmetrization of a Propane-1,3-diol to Introduce the Quaternary Chiral Center of an AMG 176 Drug Substance Intermediate |
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| المؤلفون: | Margaret M. Faul, Padmini K. Ananthoji, Athimoolam Arunachalampillai, Matthew G. Beaver, Yuan-Qing Fang, Simon J. Hedley, Brian S. Lucas, Jason S. Tedrow |
| المصدر: | Synthesis. |
| بيانات النشر: | Georg Thieme Verlag KG, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Organic Chemistry, Catalysis |
| الوصف: | A chiral Cu(II)-PyBOX complex was prepared and utilized to accomplish desymmetrization of a 1,3-diol en route to AMG 176. An expedient synthesis of the racemic 1,3-diol is described, in addition to efforts for rapid optimization and subsequent kilogram-scale execution of the desymmetrization process to generate material for pre-clinical activities. An overview of the kilogram-scale synthesis of the Cu(II)-PyBOX complex is provided. |
| تدمد: | 1437-210X 0039-7881 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e0be3ceb580e7601ab70fb81bd273d8f https://doi.org/10.1055/a-1989-2633 |
| رقم الأكسشن: | edsair.doi...........e0be3ceb580e7601ab70fb81bd273d8f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437210X 00397881 |
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