Solubility, solvent effect, and modelling of oxcarbazepine in mono-solvents and N-methyl-2-pyrrolidone + water solvent mixtures at different temperatures and its application for the preparation of nanosuspensions
التفاصيل البيبلوغرافية
العنوان:
Solubility, solvent effect, and modelling of oxcarbazepine in mono-solvents and N-methyl-2-pyrrolidone + water solvent mixtures at different temperatures and its application for the preparation of nanosuspensions
A solid–liquid equilibrium technique was used to measure the solubility of oxcarbazepine in a mono-solvent and a solvent mixture in the temperature range of 288.15–308.15 K under atmospheric pressure. Oxcarbazepine in N-methyl-2-pyrrolidone (NMP) showed the highest solubility. The KAT-LSER model was applied to determine solvent effect on the solubility of oxcarbazepine in mono-solvents at 298.15 K; the dipolarity–polarizability and cohesive energy density, as the Hildebrand solubility parameter, of the solvent had a greater effect on oxcarbazepine solubility than other parameters. The solubility results of oxcarbazepine in the mono-solvents and mixed (NMP + water) solvents were correlated by applying various models. The oxcarbazepine dissolution in the mono-solvents and mixed (NMP + water) solvents was endothermic and spontaneous. Oxcarbazepine nanosuspensions were prepared based on these solubility results of oxcarbazepine in a mono-solvent and mixed (NMP + water) solvent; the average particle size of all oxcarbazepine nanosuspensions was smaller than 200 nm. The experimental and calculated solubility results of oxcarbazepine may be utilized in drug development through the application of solubilization techniques to increase the bioavailability of poorly water-soluble drugs.
