Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway
| العنوان: | Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway |
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| المؤلفون: | Kung-Ta Lee, Yao-Haur Kuo, Chia-Ching Liaw, Hung-Tse Huang, Chun-Tang Chiou |
| المصدر: | Journal of Agricultural and Food Chemistry. 69:6271-6280 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, MAPK/ERK pathway, chemistry.chemical_classification, medicine.drug_class, 010401 analytical chemistry, NF-κB, General Chemistry, 01 natural sciences, Anti-inflammatory, 0104 chemical sciences, Mapk signaling pathway, Terpene, chemistry.chemical_compound, chemistry, Biochemistry, Triterpene, medicine, General Agricultural and Biological Sciences, Quercetin, 010606 plant biology & botany, EC50 |
| الوصف: | Five new triterpene acids, mesonaic acids A-C (1-3), 2α,3α,19α-trihydroxy-24-nor-4(23),12-oleanadien-28-oic acid (4), and 3α,19α,22α-trihydroxy-2-oxo-12-ursen-28-oic acid (5), and 10 known triterpene acid compounds (6-15) were isolated from a methanolic extract of Mesona procumbens. Triterpenes 1-3 possess unusual hexacyclic skeletons with a 13α,27-cyclopropane ring. Regarding their anti-inflammatory activity, compounds 1-3, 6, and 7 inhibited NO production with EC50 values lower than 15 μM, which were better than that of the positive control quercetin. Compounds 1-3, 6, and 7 markedly decreased levels of the inducible iNOS and COX-2 proteins in macrophages by inhibiting the activation of NF-κB through interference with the MAPK signaling pathway. Based on these data, compounds 1-3, 6, and 7 have great potential as NO inhibitors. |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e22c7cb601fea8bbabec4e979f08ff30 https://doi.org/10.1021/acs.jafc.1c01810 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........e22c7cb601fea8bbabec4e979f08ff30 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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