FC062: Baseline Soluble Immune Checkpoints Predict Relapse Risk in PR3-Anca Vasculitis Following Rituximab Induction Therapy
| العنوان: | FC062: Baseline Soluble Immune Checkpoints Predict Relapse Risk in PR3-Anca Vasculitis Following Rituximab Induction Therapy |
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| المؤلفون: | Andreas Kronbichler, Gabriele Gamerith, Finn Mildner |
| المصدر: | Nephrology Dialysis Transplantation. 37 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Transplantation, Nephrology |
| الوصف: | BACKGROUND AND AIMS We investigated whether soluble immune checkpoints (sICPs) predict treatment-resistance, relapse risk and risk of infections in patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). METHOD Plasma levels of sICPs were measured by enzyme-linked immunosorbent assay from samples obtained at baseline and during follow-up from patients with AAV in the RAVE trial and were correlated with selected clinical outcomes. Log-rank test was used to evaluate survival benefits, and optimal cut-off values of the marker molecules were calculated using Yeldons J. RESULTS Among 95 patients receiving rituximab as induction therapy, lower soluble (s)Lag-3 (3000 pg/mL) were predictive of not achieving remission. Among patients with remission, 32.9% relapsed with a median relapse free survival of 5.64 months. Low baseline values of sTim-3 ( CONCLUSION Rituximab-treated patients achieved remission less frequently when sLag-3 was low and sCD27 was high. Higher expression of sTim-3, sCD27 and sBTLA at baseline was associated with a lower risk of relapse in PR3-ANCA vasculitis following rituximab. These results will require confirmation in future studies, but may contribute to personalized medicine in AAV. |
| تدمد: | 1460-2385 0931-0509 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e272fcd567da957ed40671cc5d7c565d https://doi.org/10.1093/ndt/gfac110.002 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........e272fcd567da957ed40671cc5d7c565d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602385 09310509 |
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