| الوصف: |
Background: Coagulase Negative Satphylococci (CoNS) were once thought to be non-pathogenic skin contaminants when recovered from culture media, but the usage of intravenous and implantable devices and increase in the number of immune - compromised patients in hospitals, they have now emerged as a major contributor of hospital acquired infections. The number of CoNS with enhanced resistance to glycopeptides (especially vancomycin) has been observed to be on the rise in the recent decades. Therefore, this research was done to recognize the clinical isolates of CoNS and to recognize various drug resistance with distinct mention to Vancomycin. Aim: This study aimed to isolate Coagulase Negative Staphylococci from different clinical specimens and to determine antimicrobial susceptibility pattern of all the isolates. From January 2021 to December 2021, Methods: this study was conducted in the Department of Microbiology at the School of Medical Sciences & Research, SMSR, Sharda University, Greater Noida. Total 341 CoNS were recovered in 1 year duration time from various clinical samples. Descriptive statistics like frequency table, mean, proportions were used. Analysis was done by SPS software. A total of 341 isolates of coagulase negative staphylococci Results: (CoNS) were obtained from various specimens out of which 150 (44%) were found to be clinically signicant. Maximum number of clinically signicant CoNS were recovered in the age group 0-9 years 29 (19.3%) followed by age group, ≥ 60 years: 27 (18%). Clinically signicant CoNS were isolated in maximum number from blood samples (n=51, 34%) followed by pus (n=35, 23.3%). Samples received from patients housed in the neonatal intensive care unit yielded the maximum number of clinically signicant CoNS isolates, 31 (20.7%). Staphylococcus.epidermidis was found to be the most commonly associated clinically signicant CoNS with infection 72 (48%) followed by Staphylococcus haemolyticus 42 (28%). MIC by microbroth dilution and E test was also done on all clinically signicant isolates of CoNS for vancomycin, all isolates were within the susceptible range with none of the isolates being resistant to vancomycin(with MIC = |
