Synthesis and Characterization of Citrusinol Acetyl Derivative, and Its Interactions with DNA and BSA: 13C NMR, 1H NMR, HMBC, Fluorescence, UV–Vis spectrum, and Molecular Docking
| العنوان: | Synthesis and Characterization of Citrusinol Acetyl Derivative, and Its Interactions with DNA and BSA: 13C NMR, 1H NMR, HMBC, Fluorescence, UV–Vis spectrum, and Molecular Docking |
|---|---|
| المؤلفون: | G. S. Lu, X. X. Hu, Y. Ye, L. H. He, J. Y. Huang, G. T. Huang, X. Tan, Z. F. Huang |
| المصدر: | Russian Journal of Physical Chemistry A. 95:1394-1401 |
| بيانات النشر: | Pleiades Publishing Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | UV-VIS Spectrum, Crystallography, biology, Heteronuclear molecule, Hydrogen bond, Chemistry, biology.protein, Proton NMR, Physical and Theoretical Chemistry, Carbon-13 NMR, Bovine serum albumin, Spectroscopy, Fluorescence |
| الوصف: | Citrusinol was regarded as an antineoplastic agent, and acetyl-citrusinol was synthesized as a new derivative of citrusinol. The interactions of bovine serum albumin (BSA) and calf thymus DNA (ct-DNA) with citrusinol and acetyl-citrusinol were studied. The structure of acetyl-citrusinol was identified by nuclear magnetic resonance (13C NMR, 1H NMR) and heteronuclear multiple-bond correlation (HMBC). Fluorescence spectrum and molecular docking were used to investigate the interactions of citrusinol and acetyl-citrusinol with BSA. The UV–Vis spectroscopy was used to study the interactions of citrusinol and acetyl-citrusinol with ct-DNA. The citrusinol and acetyl-citrusinol combining with BSA showed the fluorescence quenching and a decrease in the maximum emission wavelength. The molecular docking results showed that there were stable combinations of citrusinol and acetyl-citrusinol with BSA. Thus, the interactions between citrusinol and acetyl-citrusinol with BSA were mainly hydrophobic and hydrogen bonding. According to the UV–Vis spectrum, citrusinol, and acetyl-citrusinol interacted with ct-DNA via electrostatic interaction. |
| تدمد: | 1531-863X 0036-0244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e537ba3185a13b7da248e3a9dd494ed1 https://doi.org/10.1134/s0036024421070128 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........e537ba3185a13b7da248e3a9dd494ed1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1531863X 00360244 |
|---|