The development of holography for large cryogenic bubble chambers, which extended over almost one decade, is described. It culminated in the successful application of this ambitious technique to the 15-foot Bubble Chamber at Fermilab. During an exposure to the neutrino beam, produced by 800 GeV/c protons on the production target, over 110'000 good holograms were taken simultaneously with conventional photographs. Bubble tracks with sizes as small as 100 μm within a volume of ∼1.5 m3 could be recorded with good contrast, improving the resolution over the standard optics by a factor of four.