A four-component domino reaction for the synthesis of novel bridgehead nitrogen-containing pyrido[1,2-d][1,4]diazepines
| العنوان: | A four-component domino reaction for the synthesis of novel bridgehead nitrogen-containing pyrido[1,2-d][1,4]diazepines |
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| المؤلفون: | Hong-bo Tan, Yuan-Hui Yu, Zhongzhu Chen, Wei Zhang, Ze-Hui Qi, Zhigang Xu, Ying Tang, Dian-Yong Tang, Rui Wang |
| المصدر: | New Journal of Chemistry. 46:592-598 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Chemistry, Ring (chemistry), Combinatorial chemistry, Catalysis, D-1, chemistry.chemical_compound, chemistry, Cascade reaction, Intramolecular force, Functional group, Materials Chemistry, Michael reaction, Molecule |
| الوصف: | An efficient one-pot four-component reaction for the synthesis of a new family of novel bridgehead nitrogen-containing pyrido[1,2-d][1,4]diazepines has been described and its mechanism has been proposed, which follows a ring-closure and ring-cleavage pathway. The protocol involved a cyclization through γ-selective C-C bond formation, an intramolecular Michael addition and a ring-opening of pyranone ring under refluxing condition with high to excellent yields. The advantages of this methodology, including the use of easily available raw materials and an inexpensive catalyst, an open-air reaction setup, wide functional group tolerance, and Gram-scale synthesis, make the developed methodology a practical way to access novel pyrido[1,2-d][1,4]diazepines and functionalized tricyclic or polycyclic fused 1,4-diazepins as well as novel analogs of important biologically active molecules. |
| تدمد: | 1369-9261 1144-0546 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e5fe342724d884a3f2269e98018aa689 https://doi.org/10.1039/d1nj04233e |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........e5fe342724d884a3f2269e98018aa689 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13699261 11440546 |
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