NEW METHOD DEVELOPMENT AND VALIDATION FOR HYDRAZINE IN PANTOPRAZOLE SODIUM SESQUIHYDRATE USING RP-HPLC
| العنوان: | NEW METHOD DEVELOPMENT AND VALIDATION FOR HYDRAZINE IN PANTOPRAZOLE SODIUM SESQUIHYDRATE USING RP-HPLC |
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| المؤلفون: | SudharshanaCharyulu S., null T. Krishnamohan, N. Sundara Rao, null V.V.K.P.L.N.Murty, null Y.L.N. Murthy, J. V. Shanmukha Kumar |
| المصدر: | RASAYAN Journal of Chemistry. 15:1403-1410 |
| بيانات النشر: | Rasayan Journal of Chemistry, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Energy, General Chemical Engineering, General Chemistry, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry |
| الوصف: | Pantoprazole sodium sesquihydrate is a white crystalline powder. Quantification of hydrazine through derivatization with salicylaldehyde was investigated by RP-HPLC analysis and found to be accurate and robust in achieving detection limits as low as 3.1 ppm. HPLC analysis of hydrazine was done using Inertsil ODS-3V (250 mm ×4.6 mm) 5µm column, and ammonium dihydrogen phosphate (10 gm) in water (1000 mL) was used as a buffer. The mobile phase used was in the ratio of buffer and methanol (25:75 v/v). With a constant flow rate (1.0 mL/min), elution at 360 nm was monitored. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with reference to system suitability, linearity, precision, accuracy, and robustness. Keywords: Low-Level Determination, Hplc, Hydrazine, Pantoprazole Sodium Sesquihydrate, Hydrazine. |
| تدمد: | 0976-0083 0974-1496 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e799c5896c80a6988ec93eb45d750054 https://doi.org/10.31788/rjc.2022.1526856 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........e799c5896c80a6988ec93eb45d750054 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09760083 09741496 |
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