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Phosphonothioate Hydrolysis by Molybdocene Dichlorides: Importance of Metal Interaction with the Sulfur of the Thiolate Leaving Group

التفاصيل البيبلوغرافية
العنوان: Phosphonothioate Hydrolysis by Molybdocene Dichlorides: Importance of Metal Interaction with the Sulfur of the Thiolate Leaving Group
المؤلفون: Kristina M. Dill, Louis Y. Kuo, Adria K. Dortignacq, Devon C. Baker
المصدر: Organometallics. 32:4759-4765
بيانات النشر: American Chemical Society (ACS), 2013.
سنة النشر: 2013
مصطلحات موضوعية: inorganic chemicals, Aqueous solution, Organic Chemistry, Leaving group, chemistry.chemical_element, macromolecular substances, environment and public health, Phosphonate, Medicinal chemistry, Sulfur, Inorganic Chemistry, chemistry.chemical_compound, Hydrolysis, chemistry, Cyclopentadienyl complex, Organic chemistry, Physical and Theoretical Chemistry, Metallocene, Bond cleavage
الوصف: The metallocene bis(cyclopentadienyl)molybdenum(IV) dichloride Cp2MoCl2 hydrolyzes O,S-diethyl phenylphosphonothioate (1) with only P–S scission to yield a phosphonate under mild aqueous conditions. In terms of degrading phosphonothioate neurotoxins, exclusive cleavage of the P–S linkage is preferred, for P–O scission yields another toxic phosphonothioate. Structure–activity relationship studies were undertaken with various phosphonothioates to test the hypothesis for the exclusive P–S scission by Cp2Mo(aq). Kinetics data show that the rates of phosphonothioate hydrolysis correspond to the size of the alkanethiolate leaving group on treatment with Cp2MoCl2. This suggests that the exclusive P–S scission of 1 is due to the interaction between the thiophilic Cp2Mo with the sulfur site of the P–SR linkage.
تدمد: 1520-6041
0276-7333
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e7d276ee7b59379427e7ccf850d5ca3e
https://doi.org/10.1021/om400382u
رقم الأكسشن: edsair.doi...........e7d276ee7b59379427e7ccf850d5ca3e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15206041
02767333