EFFECT OF TELMISARTAN ON BLOOD GLUCOSE LEVELS AND BLOOD LIPID LEVELS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
| العنوان: | EFFECT OF TELMISARTAN ON BLOOD GLUCOSE LEVELS AND BLOOD LIPID LEVELS IN STREPTOZOTOCIN INDUCED DIABETIC RATS |
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| المؤلفون: | Siddamma Amoghimath, R N Suresha |
| المصدر: | Biomedical & Pharmacology Journal. 12:1303-1308 |
| بيانات النشر: | Oriental Scientific Publishing Company, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, business.industry, Blood lipids, Streptozotocin, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030202 anesthesiology, Internal medicine, medicine, Telmisartan, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | To evaluate the effect of telmisartan on blood glucose levels and blood lipid levels in streptozotocin induced diabetic rats. Eighteen Wistar albino rats weighing 150-200gms of either sex were randomly selected from the central animal facility, and divided into 3 groups. Diabetes was induced by injecting Streptozotocin intraperitonelly. The control group received 1% Gum acacia (oral), standard group received 0.5 mg/kg Glibenclamide (oral) and the test group received Telmisartan 7.2mg/kg body weight (oral) from 0-28 days respectively. Body weight of the individual rats were measured on the respective days before blood glucose estimation on 0, 1, 3, 7, 14, 21 & 28th day and fasting blood glucose was estimated by (ACCUCHECK) glucometer. Estimation of fasting lipid profile by lipid screening strips on 1st and 28th day. When compared to control the capillary blood glucose (CBG) levels in the Telmisartan group was less at all the intervals but comparable with that of standard drug Glibenclamide in Streptozotocin induced diabetic rats. Improved lipid profile was seen with the Telmisartan group when compared to control group in Streptozotocin induced diabetic rats. Hypoglycemic activity and improved lipid profile action was seen with Telmisartan group which is comparable to standard drug glibenclamide in streptozotocin induced diabetic albino rats. |
| تدمد: | 2456-2610 0974-6242 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e834e5fe44f3b303e5282e15e3e13559 https://doi.org/10.13005/bpj/1758 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........e834e5fe44f3b303e5282e15e3e13559 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24562610 09746242 |
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