BIOINFORMATICS EVALUATION OF CRISP2 GENE SNPs AND THEIR IMPACTS ON PROTEIN
| العنوان: | BIOINFORMATICS EVALUATION OF CRISP2 GENE SNPs AND THEIR IMPACTS ON PROTEIN |
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| المؤلفون: | null Zaid A. Hussein, null Abdulkareem A. Al-Kazaz |
| المصدر: | IRAQI JOURNAL OF AGRICULTURAL SCIENCES. 54:369-377 |
| بيانات النشر: | University of Baghdad - College of Agriculture, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Veterinary, Food Animals, Animal Science and Zoology, Horticulture, General Agricultural and Biological Sciences, Food Science, General Environmental Science |
| الوصف: | This study evaluated the CRISP2 gene's functional single nucleotide polymorphisms, and its results may be advantageous for future population-based studies and early diagnostic discoveries, particularly in developing effective treatments. The CRISP2 gene encodes a secretory protein with a high cysteine content, which belongs to the family of cysteine-rich secretory proteins (CRISP). SNPs are genetic variations that may affect a protein's structure or functionality. Prior to carrying out a broader population investigation, it is possible to evaluate suspected functional SNPs since it is challenging to uncover functional SNPs in disease-linked genes. As a result, using various bioinformatic prediction models, the potentially harmful three SNPs of the CRISP2 gene were predicted in this in-silico study from the neutral ones. Out of a pool of 260 nsSNPs, three SNPs (L56V, M176I, and C196R) been selected to anticipate their impacts on functions and structures along with their capability to impair protein stability. Actually, two of the three SNPs in the CRISP2 gene L56V and C196R were identified as possibly detrimental, although M176I was not. But all of these SNPs dropped significantly protein stability, per the I-Mutant suite. |
| تدمد: | 2410-0862 0075-0530 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e8859d2cd9cd1f54bcf424c12c57b59d https://doi.org/10.36103/ijas.v54i2.1711 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........e8859d2cd9cd1f54bcf424c12c57b59d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24100862 00750530 |
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