α,β-Unsaturated Aldehydes Accelerate Oxymyoglobin Oxidation
| العنوان: | α,β-Unsaturated Aldehydes Accelerate Oxymyoglobin Oxidation |
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| المؤلفون: | Cameron Faustman, McClure Td, Qun Sun, Liebler Dc |
| المصدر: | Journal of Agricultural and Food Chemistry. 47:3140-3144 |
| بيانات النشر: | American Chemical Society (ACS), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Aqueous solution, Autoxidation, Electrospray ionization, General Chemistry, Medicinal chemistry, Aldehyde, chemistry.chemical_compound, Metmyoglobin, Lipid oxidation, chemistry, Myoglobin, Nonenal, Organic chemistry, General Agricultural and Biological Sciences |
| الوصف: | This study investigates the potential basis for enhancement of oxymyoglobin (OxyMb) oxidation by lipid oxidation products. Aldehydes known to be formed as secondary lipid oxidation products were combined with OxyMb in aqueous solution at 37 °C and pH 7.4. Metmyoglobin (MetMb) formation was greater in the presence of α,β-unsaturated aldehydes than their saturated counterparts of equivalent carbon chain length. Additionally, increasing chain length from hexenal through nonenal resulted in increased MetMb formation (P < 0.05). Electrospray ionization mass spectrometry (ESI-MS) revealed that OxyMb incubated with 4-hydroxynonenal (HNE) at pH 7.4 at 37 °C yielded myoglobin molecules adducted with one to three molecules of HNE from 0.5 to 2 h of incubation, respectively. A prooxidant effect of HNE was noted at pH 7.4 but was not apparent at pH 5.6 when compared to the control (P < 0.05). This appeared to be due to rapid OxyMb autoxidation at this pH compared to pH 7.4. ESI-MS demonstrated that adduction of HNE t... |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e992fe71923884122cd2959fa8997332 https://doi.org/10.1021/jf990016c |
| رقم الأكسشن: | edsair.doi...........e992fe71923884122cd2959fa8997332 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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