The Influence of Dinitrosyl Iron Complexes on the Physicochemical Characteristics of Rat Blood Components
العنوان: | The Influence of Dinitrosyl Iron Complexes on the Physicochemical Characteristics of Rat Blood Components |
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المؤلفون: | Enno K. Ruuge, Vladimir L. Lakomkin, Alexander A. Timoshin |
المصدر: | Biophysics. 64:381-386 |
بيانات النشر: | Pleiades Publishing Ltd, 2019. |
سنة النشر: | 2019 |
مصطلحات موضوعية: | 0301 basic medicine, 030102 biochemistry & molecular biology, Chemistry, Ligand, Biophysics, Albumin, Glutathione, law.invention, Spin probe, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Membrane, law, Molecule, Stearic acid, Electron paramagnetic resonance |
الوصف: | —The effect of injected intravenously dinitrosyl iron complexes with glutathione ligand on the structural and conformational characteristics of albumin, which is a primary ligand of these complexes in plasma, and on molecules of the lipid phase in the erythrocyte membrane, which constitute the microenvironment of dinitrosyl iron complexes in erythrocytes, was analyzed. The analysis of EPR spectra of 5- and 16-DOXYL stearic acid spin probes in plasma and erythrocyte suspensions before and after injection of dinitrosyl iron complexes with glutathione was performed in the experiments. It has been found that injection of these complexes into an organism does not affect the molecular motion in albumin hydrophobic regions in plasma and erythrocyte membranes, while at the same time they stimulate incorporation of charged spin labels into the erythrocyte membrane. Apparently, this was due to a change in the charge on the outer surface of the erythrocytes. |
تدمد: | 1555-6654 0006-3509 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ea0f00a2d8f2ff9e37d5fe0c6ee70aad https://doi.org/10.1134/s0006350919030242 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi...........ea0f00a2d8f2ff9e37d5fe0c6ee70aad |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15556654 00063509 |
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