Pericoronary adipose tissue density is associated with clinical disease activity in Takayasu arteritis and coronary arterial inflammation measured by 68Ga-DOTATATE PET in atherosclerosis
| العنوان: | Pericoronary adipose tissue density is associated with clinical disease activity in Takayasu arteritis and coronary arterial inflammation measured by 68Ga-DOTATATE PET in atherosclerosis |
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| المؤلفون: | Roie Manavaki, Elizabeth P.V. Le, Deepa Gopalan, Yuan Huang, Christopher Wall, Justin C. Mason, Ben Ariff, Christopher Patrick Uy, Damini Dey, James H. F. Rudd, Jason M. Tarkin, Piotr J. Slomka, Enrico Tombetti, Martin R. Bennett, M R Dweck |
| المصدر: | European Heart Journal. 41 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Aorta, medicine.diagnostic_test, biology, business.industry, C-reactive protein, Takayasu's arteritis, Adipose tissue, Inflammation, medicine.disease, Atheroma, Positron emission tomography, Internal medicine, medicine.artery, medicine, biology.protein, Cardiology, Arteritis, medicine.symptom, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background Coronary artery disease (CAD) is an under-recognized complication of intense arterial inflammation in Takayasu arteritis (TAK). While pericoronary adipose tissue (PCAT) density is associated with arterial inflammation in CAD patients, this relationship has not previously been studied in TAK patients, nor directly compared with coronary arterial inflammation measured by 68Ga-DOTATATE positron emission tomography (PET). Purpose To compare PCAT density with clinical, biochemical and molecular imaging markers of inflammation in TAK and CAD patients. Methods PCAT density was quantified from computed tomography coronary angiography (CTCA) around each of the 17 coronary segments in patients with: (1) TAK and CAD, (2) atherosclerotic CAD, and (3) age and gender-matched healthy controls, using semi-automated software (Autoplaque). In TAK patients, PCAT density was compared to the Indian Takayasu Clinical Activity Score (ITAS) and high-sensitivity C-reactive protein (CRP). In CAD patients, PCAT density was compared to local arterial inflammation measured by coronary motion-frozen 68Ga-DOTATATE PET using image registration software (FusionQuant), and systemic (aortic) inflammation using 18F-fluorodeoxyglucose (FDG) PET. Data was acquired either during routine clinical care or prior research that established 68Ga-DOTATATE as an experimental marker of arterial inflammation that binds macrophage somatostatin receptor-2 in atherosclerotic plaques (NCT02021188). Results 60 patients were included (TAK, n=20; CAD, n=20; healthy, n=20). Non-calcified plaque burden (TAK: 95.2%; CAD: 90.4%, p PCAT density varied significantly among the three groups (median [IQR] TAK: −72.9 [−81.2 to -66.1] Hounsfield unit [HU]; CAD: −79.9 [−88.0 to −72.2]; healthy: −83.8 [−90.1 to −75.8] HU, p PCAT density was significantly associated with ITAS (r=0.61, p=0.004) and CRP (r=0.43, p=0.03) in TAK patients, and coronary 68Ga-DOTATATE maximum tissue-to-blood ratio (r=0.31, p Conclusion PCAT density measured by CTCA is greater in TAK than CAD patients, and is associated with clinical and biochemical markers of disease activity in TAK, and coronary arterial inflammation measured by 68Ga-DOTATATE PET in CAD. PCAT could be a useful, easy to measure marker of coronary inflammation and disease activity in both TAK and CAD. PCAT density is greater in TAK than CAD Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Wellcome Trust |
| تدمد: | 1522-9645 0195-668X 0202-1188 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::eb084394ca46dd79e604e8a1e6070ade https://doi.org/10.1093/ehjci/ehaa946.0182 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........eb084394ca46dd79e604e8a1e6070ade |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X 02021188 |
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