Eltrombopag; Romiplostim
| العنوان: | Eltrombopag; Romiplostim |
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| المؤلفون: | Waddell, Joseph Farland, Dominic A. Solimando, Jaclyn King |
| المصدر: | Hospital Pharmacy. 44:228-231 |
| بيانات النشر: | SAGE Publications, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, Romiplostim, business.industry, Stomach, Eltrombopag, Pharmacy, Urine, Gastroenterology, Bioavailability, chemistry.chemical_compound, medicine.anatomical_structure, Pharmacokinetics, chemistry, Oral administration, Internal medicine, medicine, Pharmacology (medical), CYP2C8, business, medicine.drug |
| الوصف: | PHARMACOKINETICS Eltrombopag demonstrates dose-dependant and linear pharmacokinetics. The bioavailability is estimated as at least 52% following oral administration. Eltrombopag is best absorbed on an empty stomach; plasma concentrations may be reduced by 65% if the drug is taken with a high-fat meal. Time to peak concentration is 2 to 6 hours following oral administration. Coadministration with cations such as magnesium, aluminum, zinc, and iron may reduce absorption by as much as 70%. Eltrombopag is highly protein bound (greater than 99%). The drug is extensively metabolized in the liver via oxidation by CYP1A2 and CYP2C8, and it is glucuronidated via UGT1A1 and UGT1A3. Eltrombopag is primarily excreted in the feces (59%), with 31% excreted in the urine. The elimination half-life (t1⁄2) ranges from 9 to 35 hours. A 40% to 50% accumulation of eltrombopag may occur at doses greater than 20 mg daily. Clearance of eltrombopag is reduced by 50% in patients with moderate to severe liver dysfunction. Compared with white patients, it has been found that plasma concentrations are 70% higher in Asian pa tients and 40% higher in black patients. |
| تدمد: | 1945-1253 0018-5787 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ec02c8995a965de50c2f3fb4de46f793 https://doi.org/10.1310/hpj4403-228 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........ec02c8995a965de50c2f3fb4de46f793 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19451253 00185787 |
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