Transcription Factor TCF7L2 Genetic Study in the French Population
| العنوان: | Transcription Factor TCF7L2 Genetic Study in the French Population |
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| المؤلفون: | Raphael Scharfmann, Gema Frühbeck, Bart Staels, Beverley Balkau, Christian Dina, François Pattou, Chantal Samson, Stéphane Cauchi, David Meyre, Hélène Choquet, Philippe Froguel, Guillaume Charpentier, Volodymyr Stetsyuk, Sophie Gallina |
| المصدر: | Diabetes. 55:2903-2908 |
| بيانات النشر: | American Diabetes Association, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | 0303 health sciences, medicine.medical_specialty, education.field_of_study, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Population, Case-control study, Adipose tissue, 030209 endocrinology & metabolism, Type 2 diabetes, Biology, medicine.disease, Transcription Factor 7-Like 2, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Glucose homeostasis, education, TCF7L2, 030304 developmental biology |
| الوصف: | Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin in the DeCode study. We genotyped the two most associated variants (rs7903146 and rs12255372) in 2,367 French type 2 diabetic subjects and in 2,499 control subjects. Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55–1.83) (P = 6.0 × 10−35) and 1.60 (1.47–1.74) (P = 7.6 × 10−28), respectively. In nonobese type 2 diabetic subjects (BMI |
| تدمد: | 1939-327X 0012-1797 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ec2078aeadb6c71d0a38966411273073 https://doi.org/10.2337/db06-0474 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........ec2078aeadb6c71d0a38966411273073 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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