Abstract 813: Development of anti-Globo H ADC against cancer
| العنوان: | Abstract 813: Development of anti-Globo H ADC against cancer |
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| المؤلفون: | Chao-Pin Lee, Shih-Hsien Chuang, Chuan-Lung Hsu, Chia-Cheng Wu, Wei-Ting Sun, Ying-Shuan Lee, Yu-Chin Nieh, Yi-Jen Chen, Wei Win-Yin |
| المصدر: | Cancer Research. 78:813-813 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Cancer Research, biology, business.industry, Colorectal cancer, Cancer, H antigen, medicine.disease, Prostate cancer, Oncology, Pancreatic cancer, biology.protein, medicine, Cancer research, Antibody, Ovarian cancer, business, Lung cancer |
| الوصف: | Globo H antigen is a hexasaccharide originally isolated as a ceramide-linked glycolipid from the human breast cancer cell line MCF-7. Globo H is also highly expressed in many other cancers such as colon cancer, ovarian cancer, gastric cancer, pancreatic cancer, lung cancer, and prostate cancer. DCBD16001 is an ADC from humanized anti-Globo H antibody DCBPR1101. DCBPR1101 and DCBD16001 both show good binding affinities against Globo H antigen. DCBD16001 also shows high cytotoxicity in Globo H overexpressing cell line MCF-7 and HCC-1428 and shows no cytotoxicity in Globo H negative cell line BT-474. DCBD16001 can internalize to target cell more than 50% within 4.0 hours. In vivo evaluation data indicates that DCBD16001 shows acceptable PK profiles and good efficacy. It shows nearly 80% tumor growth inhibition in HCC-1428 xenograft model. DCBD16001 is a candidate under pre-clinical development and expected to apply IND submission within two years. Citation Format: Wei-Ting Sun, Shih-Hsien Chuang, Chao-Pin Lee, Yi-Jen Chen, Win-Yin Wei, Ying-Shuan Lee, Chuan-Lung Hsu, Yu-Chin Nieh, Chia-Cheng Wu. Development of anti-Globo H ADC against cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 813. |
| تدمد: | 1538-7445 0008-5472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::eced47ce1fbb039f99f60d1626989bb6 https://doi.org/10.1158/1538-7445.am2018-813 |
| رقم الأكسشن: | edsair.doi...........eced47ce1fbb039f99f60d1626989bb6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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