AMD070, a CXCR4 Chemokine Receptor Antagonist: Practical Large-Scale Laboratory Synthesis
| العنوان: | AMD070, a CXCR4 Chemokine Receptor Antagonist: Practical Large-Scale Laboratory Synthesis |
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| المؤلفون: | Jason B. Crawford, Gang Chen, Ernie Mceachern, Gary Bridger, Curtis Harwig, Atsma Bern, Alan Kaller, Renato Skerlj, Ian Baird, Wilson Trevor R, Bryon Carpenter, David Gauthier |
| المصدر: | Organic Process Research & Development. 12:823-830 |
| بيانات النشر: | American Chemical Society (ACS), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Organic Chemistry, Imine, chemistry.chemical_element, Zinc, Borohydride, CXCR4, Reductive amination, Chemokine Receptor Antagonist, chemistry.chemical_compound, Sodium borohydride, chemistry, Reagent, Organic chemistry, Physical and Theoretical Chemistry |
| الوصف: | An efficient and convergent four-step synthetic route to the CXCR4 chemokine receptor antagonist AMD070 (1) has been developed which employs only a single chromatographic step in the entire sequence. Novel reductive amination methods have been developed for the coupling of 2 and 3 in which a dehydrative imine formation is followed by reduction with an attenuated borohydride reagent (zinc chloride and sodium borohydride). Selective extraction methods were employed to purify synthetic intermediates and remove reagents and impurities. A procedure has also been developed to isolate 1 in a pure crystalline form. |
| تدمد: | 1520-586X 1083-6160 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ed0ea6649da5da4924011778b416c9c1 https://doi.org/10.1021/op8000993 |
| رقم الأكسشن: | edsair.doi...........ed0ea6649da5da4924011778b416c9c1 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 1520586X 10836160 |
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