This chapter highlights the role of single-cell omics in cardiovascular diseases (CVDs). It starts by highlighting CVDs as a major issue worldwide, covering their genetics and the inheritance pattern that differs from disease to disease. It then explains the two basic techniques, association studies and linkage analysis, used to determine candidate genes, reported to play an important role in the development of CVDs. It then discusses the complex genotype–phenotype correlation that is the outcome of different environmental factors playing a crucial role in disease development. It also explains techniques for single-cell analysis (SCA), which has great prospects to work miracles in the domain of CVDs. The chapter also highlights cardiometabolic phenotype analysis. By the end of the chapter, the utility of single-cell omics in special reference to CVDs has been discussed along with the challenges posed to this emerging method.
