Cutting Edge: A Threshold of B Cell Costimulatory Signals Is Required for Spontaneous Germinal Center Formation in Autoimmunity
| العنوان: | Cutting Edge: A Threshold of B Cell Costimulatory Signals Is Required for Spontaneous Germinal Center Formation in Autoimmunity |
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| المؤلفون: | Samuel W. Du, Andrea D Largent, Quan Zhen Li, Kristy Chiang, Shaun W. Jackson, David J. Rawlings, Baidong Hou, Yifan Liu, Christopher D. Thouvenel, Tanvi Arkatkar, Natali Shumlak, Jonathan Woods |
| المصدر: | The Journal of Immunology. 207:2217-2222 |
| بيانات النشر: | The American Association of Immunologists, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | CD86, Systemic lupus erythematosus, Chemistry, T cell, Immunology, Autoantibody, Germinal center, Dendritic cell, medicine.disease, medicine.anatomical_structure, medicine, Immunology and Allergy, B cell, CD80 |
| الوصف: | Cognate interactions between autoreactive B and T cells promote systemic lupus erythematosus pathogenesis by inter alia facilitating spontaneous germinal center (GC) formation. Whereas both myeloid and B cell APCs express B7 ligands (CD80 and CD86), the prevailing model holds that dendritic cell costimulation is sufficient for CD28-dependent T cell activation. In this study, we report that B cell–intrinsic CD80/CD86 deletion unexpectedly abrogates GCs in murine lupus. Interestingly, absent GCs differentially impacted serum autoantibodies. In keeping with distinct extrafollicular and GC activation pathways driving lupus autoantibodies, lack of GCs correlated with loss of RNA-associated autoantibodies but preserved anti-dsDNA and connective tissue autoantibody titers. Strikingly, even heterozygous B cell CD80/CD86 deletion was sufficient to prevent autoimmune GCs and RNA-associated autoantibodies. Together, these findings identify a key mechanism whereby B cells promote lupus pathogenesis by providing a threshold of costimulatory signals required for autoreactive T cell activation. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ef3488a7e9fc129a245f9fde16b23a9f https://doi.org/10.4049/jimmunol.2100548 |
| رقم الأكسشن: | edsair.doi...........ef3488a7e9fc129a245f9fde16b23a9f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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