Synthesis of Gold Nanoparticles with Polyamidoamine (Pamam) Generation 4 Dendrimer as Stabilizing Agent for CT Scan Contrast Agent
العنوان: | Synthesis of Gold Nanoparticles with Polyamidoamine (Pamam) Generation 4 Dendrimer as Stabilizing Agent for CT Scan Contrast Agent |
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المؤلفون: | Prima Dewi Purnamasari, A. Mutalib, Anung Pujiyanto, Effionora Anwar, Sutriyo, H. G. Adang, D. Joshita, Ristaniah, Maksum Radji |
المصدر: | Macromolecular Symposia. 353:96-101 |
بيانات النشر: | Wiley, 2015. |
سنة النشر: | 2015 |
مصطلحات موضوعية: | Materials science, Polymers and Plastics, Organic Chemistry, Dispersity, Nanoparticle, Nanotechnology, Condensed Matter Physics, Sodium borohydride, chemistry.chemical_compound, Ultraviolet visible spectroscopy, chemistry, Dynamic light scattering, Colloidal gold, Dendrimer, Materials Chemistry, Macromolecule, Nuclear chemistry |
الوصف: | Gold nanoparticles have great potential in biomedical applications as both a therapeutic and diagnostic agents. Pamam dendrimers are spherical, highly branched macromolecules with a narrow polydispersity to encapsulate and stabilize metal nanoparticles. In the preparation of metal nanoparticles, stabilizers play an important role in controlling particle size. The objectives of this study were to synthesize and characterize of gold nanoparticles. The gold nanoparticles were prepared by reduction of tetrachloroauric acid using sodium borohydride with and without addition of pamam generation 4 dendrimer as stabilizing agent. Gold nanoparticles stabilized pamam generation 4 dendrimer were characterized by Uv-Vis spectrometry, transmission electron microscopy (TEM), dynamic light scattering (DLS) and zetasizer. The result showed that UV–vis absorption spectra of gold nanoparticles without pamam G4 dendrimer at 530 nm while absorption spectra of gold–pamam G4 dendrimer at 280 nm. The absorbance peak at 280 nm related to individual of gold nanoparticle encapsulated pamam dendrimer. TEM analysis exhibits the occurrence aggregation of gold nanoparticles without pamam G4 dendrimer. DLS analysis exhibit gold nanoparticles has a particles size 88-252 nm while gold-pamam G4 dendrimer nanoparticles 2-15 nm. The addition of pamam generation 4 dendrimer on preparation of gold nanoparticles could prevent aggregation of nanoparticles through entrapment in cavity or core molecules. Au-PAMAM G4 nanoparticles 0.1 mg/ml has a greater Hounsfield unit (HU) value than iodine at the same concentration, so it has better contrast properties. Synthesis of Gold Nanoparticles with Polyamidoamine (Pamam).... Available from: https://www.researchgate.net/publication/282534500_Synthesis_of_Gold_Nanoparticles_with_Polyamidoamine_Pamam_Generation_4_Dendrimer_as_Stabilizing_Agent_for_CT_Scan_Contrast_Agent [accessed Apr 19 2018]. |
تدمد: | 1022-1360 2825-3450 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f084444d41ca6f6267acb6570149e669 https://doi.org/10.1002/masy.201550312 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi...........f084444d41ca6f6267acb6570149e669 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 10221360 28253450 |
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