Anticytomegalovirus CD4 + T Cells Are Associated With Subclinical Atherosclerosis in Persons With HIV
| العنوان: | Anticytomegalovirus CD4 + T Cells Are Associated With Subclinical Atherosclerosis in Persons With HIV |
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| المؤلفون: | David G. Harrison, Tarek S. Absi, Simon Mallal, Rama Gangula, Renu Virmani, Daniella T Fuller, Joshua A. Beckman, Meena S. Madhur, Chike O. Abana, Leslie M. Meenderink, Cathy A. Jenkins, Kenji Kawai, Christian M Warren, Rita M. Smith, Tecla M Temu, Liang Guo, Curtis L. Gabriel, Aloke V. Finn, Alexander Gelbard, Yan Ru Su, John R. Koethe, Samuel S Bailin, Matthew J. Tyska, Celestine N. Wanjalla, Spyros A. Kalams, Mona Mashayekhi |
| المصدر: | Arteriosclerosis, Thrombosis, and Vascular Biology. 41:1459-1473 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, business.industry, Human immunodeficiency virus (HIV), Congenital cytomegalovirus infection, Inflammation, medicine.disease_cause, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Subclinical atherosclerosis, Immunology, medicine, 030212 general & internal medicine, medicine.symptom, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Objective: Persons with HIV have double the risk of developing cardiovascular disease compared with the general population. A persistent and heightened immune response to cytomegalovirus coinfection may be one contributing factor, but the relationship between cytomegalovirus replication, virus-specific immune cells, and plaque burden is unclear. Approach and Results: We assessed the relationship between CD4 + T-cell subsets and carotid plaque burden in a cohort of 70 HIV-positive participants with sustained viral suppression on a single antiretroviral regimen and without known cardiovascular disease. We evaluated relationships between immune parameters, carotid plaque burden, and brachial artery flow-mediated vasodilation using multivariable linear and logistic regression models. We found that participants with carotid plaque had increased circulating CX3CR1 + ~GPR56 + ~CD57 + (ie, C~G~C) + CD4 + T cells ( P =0.03), which is a marker combination associated with antiviral and cytotoxic responses. In addition, a median of 14.4% (IQR, 4.7%–32.7%) of the C~G~C + CD4 + T-cells expressed antigen receptors that recognized a single cytomegalovirus glycoprotein-B epitope. Using immunofluorescence staining, we found that CX3CR1 + CD4 + T cells were present in coronary plaque from deceased HIV-positive persons. C~G~C + CD4 + T cells were also present in cells isolated from the aorta of HIV-negative donors. Conclusions: HIV-positive persons with carotid atheroma have a higher proportion of circulating CD4 + T-cells expressing the C~G~C surface marker combination associated with antiviral and cytotoxic responses. These cells can be cytomegalovirus-specific and are also present in the aorta. |
| تدمد: | 1524-4636 1079-5642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f0ba623f2abad0010ec9f5e9ba3d8afe https://doi.org/10.1161/atvbaha.120.315786 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........f0ba623f2abad0010ec9f5e9ba3d8afe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244636 10795642 |
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