التفاصيل البيبلوغرافية
| العنوان: |
Thermo- and pH-induced self-assembly of P(AA-b -NIPAAm-b -AA) triblock copolymers synthesized via RAFT polymerization |
| المؤلفون: |
Chia-Fen Lee, Wen-Yen Chiu, Chih-Yuan Huang, Shih-Chi Hsu, Trong-Ming Don, Chih-Yu Kuo |
| المصدر: |
Journal of Polymer Science Part A: Polymer Chemistry. 54:1109-1118 |
| بيانات النشر: |
Wiley, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Polymers and Plastics, Organic Chemistry, Chain transfer, 02 engineering and technology, Raft, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Lower critical solution temperature, Micelle, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Polymerization, Polymer chemistry, Materials Chemistry, Copolymer, Reversible addition−fragmentation chain-transfer polymerization, 0210 nano-technology, Acrylic acid |
| الوصف: |
A series of environmentally sensitive ABA triblock copolymers with different block lengths were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization from acrylic acid (AA) and N-isopropylacrylamide (NIPAAm). The GPC and 1H NMR analyses demonstrated the narrow molecular weight distribution and precise chemical structure of the prepared P(AA-b-NIPAAm-b-AA) triblock copolymers owing to the controlled/living characteristics of RAFT polymerization. The lower critical solution temperature (LCST) of the triblock copolymers could be tailored by adjusting the length of PAA block and controlled by the pH value. Under heating, the triblock copolymers underwent self-assemble in dilute aqueous solution and formed nanoparticles revealed via TEM images. Physically crosslinked nanogels induced by inter-/intra-hydrogen bonding or core-shell micelle particles thus could be obtained by changing environmental conditions. With a well-defined structure and stimuli-responsive properties, the P(AA-b-NIPAAm-b-AA) copolymer is expected to be employed as a nanocarrier for biomedical applications in controlled-drug delivery and targeting therapy. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 1109–1118 |
| تدمد: |
0887-624X |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::f1045044ba03fce6768b7bc7aa046323
https://doi.org/10.1002/pola.27950 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.doi...........f1045044ba03fce6768b7bc7aa046323 |
| قاعدة البيانات: |
OpenAIRE |
