Antisense oligonucleotides modified at 5'-end by fatty radicals effectively inhibit reproduction of influenza virus
| العنوان: | Antisense oligonucleotides modified at 5'-end by fatty radicals effectively inhibit reproduction of influenza virus |
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| المؤلفون: | Sergei V. Vinogradov, Vsevolod Kiselev, Alexander V. Krivonos, Eugenii S. Severin, Alexander V. Kabanov, A. V. Ovcharenko, N. S. Melik-Nubarov |
| المصدر: | Collection of Czechoslovak Chemical Communications. 55:587-589 |
| بيانات النشر: | Institute of Organic Chemistry & Biochemistry, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Biochemistry, Oligonucleotide, Chemistry, Radical, media_common.quotation_subject, Antisense oligonucleotides, General Chemistry, Viral disease, Reproduction, Molecular biology, Virus, Antisense RNA, media_common |
| الوصف: | To enhance penetration of oligonucleotides ("oligos") into cells it was suggested that they should be chemically modified by fatty radicals at 5'-end. Two modified by undecanol at 5'-end phosphate group oligos, namely, oligo complementary to the protein binding sites, located at the influenza virus polymerases encoding RNA, and oligo complementary to the polyadenylation signal of the polymerase 3 encoding RNA were synthesized using DNA-synthetisator. These modified oligos effectively suppressed the influenza A/PR8/34 virus reproduction and inhibited the synthesis of virus-specific proteins in MDCK cells. The non-modified antisense oligos and modified nonsense oligos did not affect the virus development under the same conditions. |
| تدمد: | 1212-6950 0010-0765 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f112d84c861892bdaa5f40173b58fd61 https://doi.org/10.1135/cccc19900587 |
| رقم الأكسشن: | edsair.doi...........f112d84c861892bdaa5f40173b58fd61 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12126950 00100765 |
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