Unterschiedliche Heilungstendenz der Refluxösophagitis nach Omeprazol und Ranitidin: Ergebnisse einer deutsch-österreichisch-schweizerischen Multizenterstudie
| العنوان: | Unterschiedliche Heilungstendenz der Refluxösophagitis nach Omeprazol und Ranitidin: Ergebnisse einer deutsch-österreichisch-schweizerischen Multizenterstudie |
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| المؤلفون: | R. Schiessel, Ernst-Otto Riecken, G. Lux, L. Witzel, H. G. Dammann, A. L. Blum, M. Wienbeck, M. Rehner, J. Berger |
| المصدر: | DMW - Deutsche Medizinische Wochenschrift. 111:123-128 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, Antagonist, Heartburn, General Medicine, biology.organism_classification, Gastroenterology, Ranitidine, Multicenter study, Internal medicine, Pyrosis, medicine, medicine.symptom, Reflux esophagitis, business, Omeprazole, Morning, medicine.drug |
| الوصف: | The effectiveness of a single, morning oral dose of 40 mg omeprazole or a twice daily oral dose of 150 mg ranitidine was compared in a randomized endoscopically controlled double-blind trial at 37 clinics in Austria, Germany and Switzerland. A total of 178 out-patients in stages I-IVa (after Savary and Miller) were entered into the trial: 78 in stage I, 60 in stage II, 27 in stage III, and in 13 in stage IVa. As early as at the end of the third treatment week there was a significantly higher rate of complete healing or reduction into a lower stage with omeprazole than ranitidine (85% vs 67%; P less than 0.02). After six treatment weeks, healing tendency after omeprazole compared with ranitidine was 85% vs 45% (P less than 0.04). Omeprazole also brought earlier improvement in symptoms. The difference was statistically significant for heartburn (pyrosis): P less than 0.01. Both drugs were equally well tolerated and there were no clinically significant side-effects. This is the first demonstration that the ATPase inhibitor omeprazole is superior to the H2-receptor antagonist ranitidine in the treatment of reflux oesophagitis. |
| تدمد: | 1439-4413 0012-0472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f148e8338da9a507edf000398fff483b https://doi.org/10.1055/s-2008-1068412 |
| رقم الأكسشن: | edsair.doi...........f148e8338da9a507edf000398fff483b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394413 00120472 |
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