RPR120844, a Novel, Specific Inhibitor of Coagulation Factor Xa Inhibits Venous Thrombosis in the Rabbit
| العنوان: | RPR120844, a Novel, Specific Inhibitor of Coagulation Factor Xa Inhibits Venous Thrombosis in the Rabbit |
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| المؤلفون: | Ewing William R, Robert J. Leadley, Alfred P. Spada, Mark H. Perrone, Christopher T. Dunwiddie, S. Morgan, Henry W. Pauls, Valeria Chu, Jeffrey S. Bostwick, Karen D. Brown, Ross Bentley |
| المصدر: | Thrombosis and Haemostasis. 81:157-160 |
| بيانات النشر: | Georg Thieme Verlag KG, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Prothrombin time, Pathology, medicine.medical_specialty, medicine.drug_mechanism_of_action, medicine.diagnostic_test, business.industry, Factor Xa Inhibitor, Hematology, Pharmacology, medicine.disease, Venous thrombosis, In vivo, Antithrombotic, Medicine, Thrombus, business, Ex vivo, circulatory and respiratory physiology, Partial thromboplastin time |
| الوصف: | SummaryThe in vivo antithrombotic activity of RPR120844, a novel synthetic coagulation factor Xa (fXa) inhibitor (Ki = 7 nM), was assessed by its ability to inhibit thrombus formation in a damaged segment of the rabbit jugular vein. Intravenous dose-response studies were performed and thrombus mass (TM), activated partial thromboplastin time (APTT), prothrombin time (PT), inhibition of ex vivo fXa activity and plasma drug levels (PDL) were determined. TM, measured at the end of a 50 min infusion, was significantly reduced (p |
| تدمد: | 2567-689X 0340-6245 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f1ed83ecb09809b17f08abe7f2ff8cfa https://doi.org/10.1055/s-0037-1614434 |
| رقم الأكسشن: | edsair.doi...........f1ed83ecb09809b17f08abe7f2ff8cfa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2567689X 03406245 |
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