Hemorrhage is probably the most serious complication arising in neurosurgical procedures; it is associated with significant morbidity and mortality. Neurosurgical patients may face several risk factors of bleeding: past medical comorbidities, particular neurosurgical techniques and medication, intraoperative hemodynamic disturbances, and specific neurochemical mechanisms can all lead to hemostatic disorders. These hemostatic abnormalities can lead to either hemorrhagic or thrombotic complications. Neurosurgical patients are known to be particularly exposed to thromboembolic events and there are many reasons why.