The Isentropic Compression Experiment (ICE) technique has proven to be a valuable complement to the well‐established method of shock compression of condensed matter. However, whereas the high‐pressure compression response of interferometer window materials has been studied extensively under shock loading, similar knowledge of these materials under quasi‐isentropic loading is limited. We present recent experimental results on the quasi‐isentropic compression of the high‐pressure window LiF on the Veloce pulsed power generator. While it is a frequently used window material in quasi‐isentropic loading and unloading experiments, the unloading response of LiF is usually neglected. It will be shown how the strength of LiF may influence the wave profile analysis and thus the inferred compressive strength of the material being studied.