Blocking α 4 β 7 integrin delays viral rebound in SHIV SF162P3 -infected macaques treated with anti-HIV broadly neutralizing antibodies
| العنوان: | Blocking α 4 β 7 integrin delays viral rebound in SHIV SF162P3 -infected macaques treated with anti-HIV broadly neutralizing antibodies |
|---|---|
| المؤلفون: | Christine M. Fennessey, Maria Sole Cigoli, Peter D. Kwong, Brooke Grasperge, Agegnehu Gettie, Eun Sung Yang, John R. Mascola, James Blanchard, Ines Frank, Giulia Calenda, Marissa Fahlberg, Amarendra Pegu, Monica Vaccari, Thomas J. Hope, Reda Rawi, Cuiping Liu, Stephanie Maldonado, Gwo-Yu Chuang, Claudia Cicala, James Arthos, Elena Martinelli, Brandon F. Keele, Muhammad Shafique Arif, Anthony S. Fauci, Hui Geng, Tongqing Zhou |
| المصدر: | Science Translational Medicine. 13 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | biology, business.industry, medicine.drug_class, medicine.medical_treatment, Viremia, General Medicine, Immunotherapy, Simian immunodeficiency virus, medicine.disease_cause, Monoclonal antibody, medicine.disease, Virology, α4β7 integrin, Blockade, Immune system, biology.protein, Medicine, Antibody, business |
| الوصف: | Anti-HIV broadly neutralizing antibodies (bNAbs) may favor development of antiviral immunity by engaging the immune system during immunotherapy. Targeting integrin α4β7 with an anti-α4β7 monoclonal antibody (Rh-α4β7) affects immune responses in SIV/SHIV-infected macaques. To explore the therapeutic potential of combining bNAbs with α4β7 integrin blockade, SHIVSF162P3-infected, viremic rhesus macaques were treated with bNAbs only (VRC07-523LS and PGT128 anti-HIV antibodies) or a combination of bNAbs and Rh-α4β7 or were left untreated as a control. Treatment with bNAbs alone decreased viremia below 200 copies/ml in all macaques, but seven of eight macaques (87.5%) in the bNAbs-only group rebounded within a median of 3 weeks (95% CI: 2 to 9). In contrast, three of six macaques treated with a combination of Rh-α4β7 and bNAbs (50%) maintained a viremia below 200 copies/ml until the end of the follow-up period; viremia in the other three macaques rebounded within a median of 6 weeks (95% CI: 5 to 11). Thus, there was a modest delay in viral rebound in the macaques treated with the combination antibody therapy compared to bNAbs alone. Our study suggests that α4β7 integrin blockade may prolong virologic control by bNAbs in SHIVSF162P3-infected macaques. |
| تدمد: | 1946-6242 1946-6234 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f5e6d5b193c279e3f4d64c1a09533855 https://doi.org/10.1126/scitranslmed.abf7201 |
| رقم الأكسشن: | edsair.doi...........f5e6d5b193c279e3f4d64c1a09533855 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19466242 19466234 |
|---|