Adult acute lymphoblastic leukemia phenotypes defined by monoclonal antibodies
| العنوان: | Adult acute lymphoblastic leukemia phenotypes defined by monoclonal antibodies |
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| المؤلفون: | Keaven Anderson, Clara D. Bloomfield, Frederick R. Davey, Ivor Royston, Robert E. Sobol, R R Ellison, Charles A. Schiffer, Tucker W. LeBien, Janet Cuttner, Jun Minowada |
| المصدر: | Blood. 65:730-735 |
| بيانات النشر: | American Society of Hematology, 1985. |
| سنة النشر: | 1985 |
| مصطلحات موضوعية: | medicine.diagnostic_test, biology, medicine.drug_class, Calla, Immunology, Cell Biology, Hematology, Monoclonal antibody, medicine.disease, Immunofluorescence, biology.organism_classification, Biochemistry, Leukemia, Antigen, Monoclonal, medicine, Adult Acute Lymphoblastic Leukemia, biology.protein, Antibody |
| الوصف: | Pretreatment peripheral blood and/or bone marrow blasts from 90 adults with acute lymphoblastic leukemia (ALL) were analyzed as part of a prospective treatment protocol study. Specimens were tested by immunofluorescence cytofluorometry for reactivity with the following monoclonal antibodies (MoAbs): BA-1 (B cell antigen); T101, OKT11 (pan- T cell antigens [T]); 3A1 (T cell antigen); MCS-2 (myeloid antigen); J5 common ALL antigen (CALLA); BA4 (Ia antigen [Ia]); BA-2 (lymphohematopoietic antigen). Four major phenotypic groups were identified: B lineage ALL (BA-1+T-) (64%), T lineage ALL (T+BA-1-MCS-2- ) (13%), unclassified ALL (BA-1-MCS-2-CALLA-T-) (9%) and myeloid antigen ALL (MCS-2+CALLA-T-) (7%). An additional group of patients, miscellaneous ALL (7%), was comprised of cases with unusual marker profiles. In B lineage ALL, all cases tested were Ia+MCS-2-, and the vast majority were CALLA+ (84%). In T lineage ALL, 42% expressed CALLA or Ia positivity. In unclassified ALL, the predominant phenotype was Ia+BA-2+. In myeloid antigen ALL, two of four tested were 3A1+ and all cases evaluated were BA-1-. Patients with myeloid antigen ALL were older (median age, 66 years) than patients in the other groups. The T lineage ALL group had higher leukocyte counts (median WBCs, 183,000/microL) and an increased incidence of anterior mediastinal mass at presentation. All patients received identical induction therapy. In CALLA+B lineage ALL, 30 of 46 (65%) achieved a complete remission. While the number of patients evaluated was small, 9 of 9 CALLA-B- lineage ALL and only two of six myeloid antigen ALL cases responded with a complete remission. The data suggest that these MoAbs are useful in the characterization of adult ALL. |
| تدمد: | 1528-0020 0006-4971 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f5eb4dd214e7496cc6a89764a4beb5d2 https://doi.org/10.1182/blood.v65.3.730.730 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........f5eb4dd214e7496cc6a89764a4beb5d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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