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Synthesis of New Functionally Substituted Indenes, Benzofurans, and 2,5-Benzodiazocin-1(2H)-ones

التفاصيل البيبلوغرافية
العنوان: Synthesis of New Functionally Substituted Indenes, Benzofurans, and 2,5-Benzodiazocin-1(2H)-ones
المؤلفون: A. S. Zukhairaeva, N. N. Stepkina, A. V. Velikorodov, V. P. Osipova, E. A. Shustova
المصدر: Russian Journal of Organic Chemistry. 57:575-581
بيانات النشر: Pleiades Publishing Ltd, 2021.
سنة النشر: 2021
مصطلحات موضوعية: chemistry.chemical_compound, Carbamate, Acetic acid, Phenylcarbamates, Chemistry, Ninhydrin, medicine.medical_treatment, Organic Chemistry, medicine, Phenol, Ethylenediamine, Sulfuric acid, Medicinal chemistry
الوصف: The synthesis of new functionally substituted 1H-indene-1,3(2H)-diones, indenobenzofurans, and 2,5-benzodiazocines is described. The condensations of ninhydrin in concentrated sulfuric acid with 2-(mor­pholin-4-yl)ethyl and 2-(pyridin-2-yl)ethyl phenylcarbamates at 20°C and with 2,6-di-tert-butylphenol while gradually raising the temperature from 0 to 20°C gave the corresponding 2,2-disubstituted 1H-indene-1,3(2H)-diones in 62–89% yields. 6-(1-Adamantyl)-4b,9b-dihydroxy-8-methyl-4b,9b-dihydro-10H-indeno[1,2-b]benzo­furan-10-one and 6,3-di(tert-butyl)-4b,9b-dihydroxy-4b,9b-dihydro-10H-indeno[1,2-b][1]benzofuran-10-one were obtained with high yields (96–98%) by heating ninhydrin with 2-(1-adamantyl)-4-methylphenol and 2,4-di(tert-butyl)phenol, respectively, in glacial acetic acid at 60°C. Benzofurans containing an adamantyl, tert-butyl, or carbamate fragment reacted with 99% ethylenediamine at 20°C to afford 80–85% of new 2,5-benzo­diazocine derivatives.
تدمد: 1608-3393
1070-4280
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f61da0446124d64b34a34beaea285867
https://doi.org/10.1134/s1070428021040114
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........f61da0446124d64b34a34beaea285867
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16083393
10704280