EBM Analyse: Klassische DMARDs (Disease modifying antirheumatic drugs) und Immunsuppressiva bei Arthritis und Uveitis
| العنوان: | EBM Analyse: Klassische DMARDs (Disease modifying antirheumatic drugs) und Immunsuppressiva bei Arthritis und Uveitis |
|---|---|
| المؤلفون: | Arnd Heiligenhaus, H Michels, Tim Niehues, Manfred Zierhut, Sibylle Winterhalter, Matthias D. Becker |
| المصدر: | Klinische Monatsblätter für Augenheilkunde. 224:520-525 |
| بيانات النشر: | Georg Thieme Verlag KG, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, genetic structures, business.industry, Arthritis, Azathioprine, Disease, Controlled studies, Evidence level, medicine.disease, Dermatology, Ophthalmology, immune system diseases, Cyclosporin a, Immunology, medicine, skin and connective tissue diseases, Antirheumatic drugs, business, Uveitis, medicine.drug |
| الوصف: | The best experience in the use of DMARDs/immunosuppressive drugs for treatment of juvenile idiopathic arthritis (JIA) and JIA-associated uveitis has been obtained with MTX. Controlled studies on the treatment of uveitis in JIA, however, are still lacking; this is also true for other DMARDs/immunosuppressive drugs. Thus, the grading of the evidence level for these substances only reaches evidence level III (expert opinion, clinical experience or descriptive studies). For the treatment of uveitis in JIA the utility of MTX in comparison to the new biological substance classes (e. g., tumor necrosis factor-alpha, blockers, interleukin-1 receptor antagonist) will have to be examined. Experience with Mycophenolate mofetil (MMF) in JIA uveitis is limited to single cases. According to data from a retrospective analysis cyclosporin A (CsA) appears to have a limited efficacy in JIA uveitis. The results with azathioprine are not consistent. Controlled studies which led to the approval of drugs for JIA are also mandatory for uveitis to offer the most effective and safe therapy for children. |
| تدمد: | 1439-3999 0023-2165 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f6fcd733e6b6a88c25aa6a821d534e59 https://doi.org/10.1055/s-2007-963094 |
| رقم الأكسشن: | edsair.doi...........f6fcd733e6b6a88c25aa6a821d534e59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14393999 00232165 |
|---|