A novel Ce-P-O catalyst for the selective catalytic reduction of NO with NH3 was synthesized. The Ce-P-O catalyst was calcined at 500 °C and showed higher deNOx activity (NO conversion > 90%) with the temperature range of 300–550 °C and at GHSV = 20 000 h−1. The NO conversion was not significantly affected by the presence of H2O and SO2. By comparison with the commercial V-W-Ti catalyst, the Ce-P-O catalyst exhibited better resistance to deactivation due to K2O poisoning.