Interference With Peroxisome Proliferator-Activated Receptor-γ in Vascular Smooth Muscle Causes Baroreflex Impairment and Autonomic Dysfunction
| العنوان: | Interference With Peroxisome Proliferator-Activated Receptor-γ in Vascular Smooth Muscle Causes Baroreflex Impairment and Autonomic Dysfunction |
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| المؤلفون: | Pimonrat Ketsawatsomkron, Giulianna R. Borges, Anthony P. Thompson, Durga P. Mohapatra, Aaron D. Mickle, Kamal Rahmouni, Curt D. Sigmund, Martin D. Cassell, Donald A. Morgan |
| المصدر: | Hypertension. 64:590-596 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Sympathetic nervous system, medicine.medical_specialty, Vascular smooth muscle, business.industry, Vasodilation, Nodose Ganglion, Baroreflex, Transient receptor potential channel, medicine.anatomical_structure, Endocrinology, Internal medicine, cardiovascular system, Internal Medicine, Medicine, medicine.symptom, business, Receptor, Vasoconstriction |
| الوصف: | S-P467L mice expressing dominant negative peroxisome proliferator-activated receptor-γ selectively in vascular smooth muscle exhibit impaired vasodilation, augmented vasoconstriction, hypertension, and tachycardia. We hypothesized that tachycardia in S-P467L mice is a result of baroreflex dysfunction. S-P467L mice displayed increased sympathetic traffic to the heart and decreased baroreflex gain and effectiveness. Carotid arteries exhibited inward remodeling but no changes in distensibility or stress/strain. Aortic depressor nerve activity in response to increased arterial pressure was blunted in S-P467L mice. However, the arterial pressure and heart rate responses to aortic depressor nerve stimulation were unaltered in S-P467L mice, suggesting that the central and efferent limbs of the baroreflex arc remain intact. There was no transgene expression in nodose ganglion and no change in expression of the acid-sensing ion channel-2 or -3 in nodose ganglion. There was a trend toward decreased expression of transient receptor potential vanilloid-1 receptor mRNA in nodose ganglion, but no difference in the immunochemical staining of transient receptor potential vanilloid-1 receptor in the termination area of the left aortic depressor nerve in S-P467L mice. Although there was no difference in the maximal calcium response to capsaicin in cultured nodose neurons from S-P467L mice, there was decreased desensitization of transient receptor potential vanilloid-1 receptor channels. In conclusion, S-P467L mice exhibit baroreflex dysfunction because of a defect in the afferent limb of the baroreflex arc caused by impaired vascular function, altered vascular structure, or compromised neurovascular coupling. These findings implicate vascular smooth muscle peroxisome proliferator activated receptor-γ as a critical determinant of neurovascular signaling. |
| تدمد: | 1524-4563 0194-911X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f9899cde3ed39357007b7deac92bf52e https://doi.org/10.1161/hypertensionaha.114.03553 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........f9899cde3ed39357007b7deac92bf52e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244563 0194911X |
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