Saponins From Platycodon grandiflorum Reduces Cisplatin-Induced Intestinal Toxicity in Mice through Endoplasmic Reticulum Stress-Activated Apoptosis
| العنوان: | Saponins From Platycodon grandiflorum Reduces Cisplatin-Induced Intestinal Toxicity in Mice through Endoplasmic Reticulum Stress-Activated Apoptosis |
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| المؤلفون: | Qiong Shen, Xiao-Meng Wei, Jun-Nan Hu, Ming-Han Li, Ke Li, Si-Min Qi, Xiang-Xiang Liu, Zi Wang, Wei Li, Ying-Ping Wang |
| المصدر: | The American Journal of Chinese Medicine. 50:1927-1944 |
| بيانات النشر: | World Scientific Pub Co Pte Ltd, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Complementary and alternative medicine, General Medicine |
| الوصف: | Saponins from the roots of Platycodon grandiflorum, an edible medicinal plant, have shown a wide range of beneficial effects on various biological processes. In this study, an animal model was established by a single intraperitoneal injection of cisplatin (20[Formula: see text]mg/kg) for evaluating the protective effects of saponins from the roots of P. grandiflorum (PGS, 15[Formula: see text]mg/kg and 30[Formula: see text]mg/kg) in mice. The results indicated that PGS treatment for 10 days restored the destroyed intestinal mucosal oxidative system, and the loosened junctions of small intestinal villi was significantly improved. In addition, a significant mitigation of apoptotic effects deteriorated by cisplatin exposure in small intestinal villi was observed by immunohischemical staining. Also, western blot showed that PGS could effectively prevent endoplasmic reticulum (ER) stress-induced apoptosis caused by cisplatin in mice by restoring the activity of PERK (an ER kinase)-eIF2[Formula: see text]-ATF4 signal transduction pathway. Furthermore, molecular docking results of main saponins in PGS suggested a better binding ability with target proteins. In summary, the present work revealed the underlying protective mechanisms of PGS on intestinal injury induced by cisplatin in mice. |
| تدمد: | 1793-6853 0192-415X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f9cf546a3d374ea977c8c6604cecf768 https://doi.org/10.1142/s0192415x22500823 |
| رقم الأكسشن: | edsair.doi...........f9cf546a3d374ea977c8c6604cecf768 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17936853 0192415X |
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