Prognostic Value of Bone Marrow Metabolism on Pretreatment 18F-FDG PET/CT in Patients with Metastatic Melanoma Treated with Anti-PD-1 Therapy
| العنوان: | Prognostic Value of Bone Marrow Metabolism on Pretreatment 18F-FDG PET/CT in Patients with Metastatic Melanoma Treated with Anti-PD-1 Therapy |
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| المؤلفون: | Sunil Reddy, Benjamin L. Franc, Lisa C. Zaba, Farshad Moradi, Carina Mari Aparici, Guido Davidzon, Ryusuke Nakamoto, Tie Liang, Judy Nguyen, Andrei Iagaru |
| المصدر: | Journal of Nuclear Medicine. 62:1380-1383 |
| بيانات النشر: | Society of Nuclear Medicine, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, PET-CT, business.industry, Melanoma, medicine.medical_treatment, Immunosuppression, Immunotherapy, medicine.disease, Systemic inflammation, Gastroenterology, medicine.anatomical_structure, Internal medicine, White blood cell, medicine, Absolute neutrophil count, Radiology, Nuclear Medicine and imaging, Bone marrow, medicine.symptom, business |
| الوصف: | Purpose: To investigate the prognostic value of 18F-FDG PET/CT parameters in melanoma patients before beginning anti-PD-1 therapy. Methods: Imaging parameters including SUVmax, metabolic tumor volume (MTV), and bone marrow to liver SUVmean ratio (BLR) were measured from baseline PET/CT in 92 patients before the start of anti-PD-1 therapy. Association with survival and imaging parameters combined with clinical factors was evaluated. Clinical and laboratory data between high (> median) and low (≤ median) BLR groups were compared. Results: Multivariate analyses demonstrated that BLR was an independent prognostic factor for PFS and OS (P = 0.017, P = 0.011, respectively). The high BLR group had higher levels of white blood cell count/neutrophil count and C-Reactive Protein than the low BLR group (P < 0.05). Conclusion: Patients with high BLR were associated with poor PFS and OS, potentially explained by evidence of systemic inflammation known to be associated with immunosuppression. |
| تدمد: | 2159-662X 0161-5505 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fb1b714d3444ffaf85ebfb12d8fb45d8 https://doi.org/10.2967/jnumed.120.254482 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........fb1b714d3444ffaf85ebfb12d8fb45d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2159662X 01615505 |
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