The Identification and Significance of a Thr→Pro Polymorphism in Kringle IV Type 8 of Apolipoprotein(a)
| العنوان: | The Identification and Significance of a Thr→Pro Polymorphism in Kringle IV Type 8 of Apolipoprotein(a) |
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| المؤلفون: | H. J. M. Van Rijn, F.R. Leus, J. Prins, Bonno N. Bouma, Y. Y. Van Der Hoek, J. J. P. Kastelein |
| المصدر: | Thrombosis and Haemostasis. 77:0949-0954 |
| بيانات النشر: | Georg Thieme Verlag KG, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Genetics, Apolipoprotein B, biology, Plasmin, Lysine, Locus (genetics), Hematology, Molecular biology, biology.protein, medicine, Gene, Allele frequency, Binding domain, Lipoprotein, medicine.drug |
| الوصف: | SummaryElevated plasma levels of lipoprotein(a) [Lp(a)] represent a significant independent risk factor for the development of atherosclerosis. Interindividual levels of apo(a) vary over 1000-fold and are mainly due to inheritance that is linked to the locus of the apolipoprotein(a) [apo(a)] gene. The apo(a) gene encodes multiple repeats of a sequence exhibiting up to 85% DNA sequence homology with plasminogen kringle IV (K.IV), a lysine binding domain. In our search for sequence polymorphisms in the K.IV coding domain, we identified a polymorphism predicting a Thr→Pro substitution located at amino acid position 12 of kringle IV type 8 of apo(a). The functional and clinical significance of this polymorphism was analysed in a case-control study and by comparing the in vitro lysine binding characteristics of the two Lp(a) subtypes.The case-control study (involving 153 subjects having symptomatic atherosclerosis and 153 age and gender matched normolipidemic controls) revealed an overall allele frequency for the Thr12-→Pro substitution in kringle IV type 8 of 14% and a negative association between presence of the Pro12-subtype and symptomatic atherosclerosis (p |
| تدمد: | 2567-689X 0340-6245 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fcab32dc2182c91b481597024452b550 https://doi.org/10.1055/s-0038-1656083 |
| رقم الأكسشن: | edsair.doi...........fcab32dc2182c91b481597024452b550 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2567689X 03406245 |
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