Anti-SARS-CoV-2 vaccination in adolescent and adult patients with juvenile-onset systemic lupus erythematosus: tolerability and impact on disease activity
العنوان: | Anti-SARS-CoV-2 vaccination in adolescent and adult patients with juvenile-onset systemic lupus erythematosus: tolerability and impact on disease activity |
---|---|
المؤلفون: | Cecilia Beatrice Chighizola, Ilaria Suardi, Giulia Carrea, Lorenza Argolini, Maurizio Gattinara, Achille Marino, Irene Pontikaki, Roberto Caporali, Maria Gerosa |
المصدر: | Rheumatology. |
بيانات النشر: | Oxford University Press (OUP), 2023. |
سنة النشر: | 2023 |
مصطلحات موضوعية: | Rheumatology, Pharmacology (medical) |
الوصف: | Objectives JSLE has a severe presentation and a remitting course. Patients with JSLE carry an increased vulnerability to infections, which also act as triggers of disease flare. Thus, vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important tool in JSLE. The objective of this study is to evaluate the tolerability and the safety of anti-SARS-CoV-2 vaccination, including the booster, in a monocentric cohort of JSLE patients. Methods Clinical records of JSLE patients who received at least one dose of any anti-SARS-CoV-2 vaccine were retrospectively reviewed. Data about disease activity, treatment, anti-SARS-CoV-2 vaccination and COVID-19 infection were collected. Results Sixty-five JSLE patients received at least one dose of anti-SARS-CoV-2 vaccination, while 46 patients completed the schedule with the booster. The rate of mild–moderate adverse events was 66%, mainly comprising fever, fatigue, arthromyalgias and pain at injection site. The rate of adverse events after the booster was similar to that registered after the first two doses. No significant changes after SARS-CoV-2 vaccination in BILAG and SLEDAI were observed. Disease flare rate (mainly LN) after immunization was 10.8%. Flares occurred predominantly in patients with moderate disease activity before immunization; accordingly, SLEDAI ≥4 identified patients at risk of flare while Lupus Low Disease Activity State (LLDAS) plays a protective role against post-vaccination flare. Conclusions This study confirms that anti-SARS-CoV-2 vaccination in JSLE is well tolerated; a strict clinical monitoring and a thoughtful choice of vaccination timing should be devoted to patients not in LLDAS due to the risk of post-vaccine flare. |
تدمد: | 1462-0332 1462-0324 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fd2650ab4f88a68e63d9eec7855c1341 https://doi.org/10.1093/rheumatology/kead047 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi...........fd2650ab4f88a68e63d9eec7855c1341 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14620332 14620324 |
---|