التفاصيل البيبلوغرافية
| العنوان: |
On the estimation of intracluster correlation for time-to-event outcomes in cluster randomized trials |
| المؤلفون: |
Neil Klar, Sumeet Kalia, Allan Donner |
| المصدر: |
Statistics in Medicine. 35:5551-5560 |
| بيانات النشر: |
Wiley, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
Statistics and Probability, Epidemiology, Random assignment, Estimator, Multivariate exponential distribution, 01 natural sciences, law.invention, Correlation, 010104 statistics & probability, 03 medical and health sciences, Intracluster correlation coefficient, 0302 clinical medicine, Randomized controlled trial, law, Censoring (clinical trials), Statistics, Econometrics, 030212 general & internal medicine, 0101 mathematics, Methodological research, Mathematics |
| الوصف: |
Cluster randomized trials (CRTs) involve the random assignment of intact social units rather than independent subjects to intervention groups. Time-to-event outcomes often are endpoints in CRTs. Analyses of such data need to account for the correlation among cluster members. The intracluster correlation coefficient (ICC) is used to assess the similarity among binary and continuous outcomes that belong to the same cluster. However, estimating the ICC in CRTs with time-to-event outcomes is a challenge because of the presence of censored observations. The literature suggests that the ICC may be estimated using either censoring indicators or observed event times. A simulation study explores the effect of administrative censoring on estimating the ICC. Results show that ICC estimators derived from censoring indicators or observed event times are negatively biased. Analytic work further supports these results. Observed event times are preferred to estimate the ICC under minimum frequency of administrative censoring. To our knowledge, the existing literature provides no practical guidance on the estimation of ICC when substantial amount of administrative censoring is present. The results from this study corroborate the need for further methodological research on estimating the ICC for correlated time-to-event outcomes. Copyright © 2016 John Wiley & Sons, Ltd. |
| تدمد: |
0277-6715 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::fd330a9d778b87f949f1802f4e70e85b
https://doi.org/10.1002/sim.7145 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi...........fd330a9d778b87f949f1802f4e70e85b |
| قاعدة البيانات: |
OpenAIRE |
