GluN2C / GluN2D subunit‐selective NMDA receptor potentiator CIQ reverses MK ‐801‐induced impairment in prepulse inhibition and working memory in Y ‐maze test in mice
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| المؤلفون: | Pratyush S. Suryavanshi, Dustin J. Stairs, Rajesh R. Ugale, D Yilmazer-Hanke, Shashank M. Dravid |
| المصدر: | British Journal of Pharmacology. 171:799-809 |
| بيانات النشر: | Wiley, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pharmacology, Allosteric modulator, nervous system, Protein subunit, Allosteric regulation, Glycine, NMDA receptor, Potentiator, Psychology, Receptor, Neuroscience, Prepulse inhibition |
| الوصف: | Background and Purpose Despite ample evidence supporting the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia, progress in the development of effective therapeutics based on this hypothesis has been limited. Facilitation of NMDA receptor function by co-agonists (d-serine or glycine) only partially alleviates the symptoms in schizophrenia; other means to facilitate NMDA receptors are required. NMDA receptor sub-types differ in their subunit composition, with varied GluN2 subunits (GluN2A-GluN2D) imparting different physiological, biochemical and pharmacological properties. CIQ is a positive allosteric modulator that is selective for GluN2C/GluN2D-containing NMDA receptors (Mullasseril et al.). |
| تدمد: | 1476-5381 0007-1188 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fd77494bef65fbfb92d6638723069ba5 https://doi.org/10.1111/bph.12518 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........fd77494bef65fbfb92d6638723069ba5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765381 00071188 |
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