Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress
| العنوان: | Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress |
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| المؤلفون: | Xiao-Yu Song, Lingyu Cui, Satoshi Onodera, Takashi Ikejima, Di Lei, Yuko Ushiki-Kaku, Mingyu Xia, Shin-ichi Tashiro, Guo-Dong Yao, Shunji Hattori, Toshihiko Hayashi, Biao Zhou, Pingping Zhang |
| المصدر: | Neurochemical Research. 42:1073-1083 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Elevated plus maze, Autophagy, Silibinin, Morris water navigation task, General Medicine, Biology, Pharmacology, Malondialdehyde, medicine.disease_cause, Biochemistry, Neuroprotection, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Immunology, medicine, 030217 neurology & neurosurgery, Oxidative stress, Neuroinflammation |
| الوصف: | Alzheimer's disease (AD) is a progressive, neurodegenerative disease. Accumulating evidence suggests that inflammatory response, oxidative stress and autophagy are involved in amyloid β (Aβ)-induced memory deficits. Silibinin (silybin), a flavonoid derived from the herb milk thistle, is well known for its hepatoprotective activities. In this study, we investigated the neuroprotective effect of silibinin on Aβ25-35-injected rats. Results demonstrated that silibinin significantly attenuated Aβ25-35-induced memory deficits in Morris water maze and novel object-recognition tests. Silibinin exerted anxiolytic effect in Aβ25-35-injected rats as determined in elevated plus maze test. Silibinin attenuated the inflammatory responses, increased glutathione (GSH) levels and decreased malondialdehyde (MDA) levels, and upregulated autophagy levels in the Aβ25-35-injected rats. In conclusion, silibinin is a potential candidate for AD treatment because of its anti-inflammatory, antioxidant and autophagy regulating activities. |
| تدمد: | 1573-6903 0364-3190 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fe5c03c64a47e08907a1530d5d772bb4 https://doi.org/10.1007/s11064-016-2141-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........fe5c03c64a47e08907a1530d5d772bb4 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15736903 03643190 |
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