Beeinflussung der Blutgerinnung durch ein niedermolekulares Heparin
| العنوان: | Beeinflussung der Blutgerinnung durch ein niedermolekulares Heparin |
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| المؤلفون: | Ellen Weber, J X de Vries, J. Harenberg, Rainer Zimmermann |
| المصدر: | DMW - Deutsche Medizinische Wochenschrift. 109:951-954 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.diagnostic_test, Factor X, Half-life, General Medicine, Heparin, Pharmacology, medicine.disease, Thrombosis, chemistry.chemical_compound, chemistry, Coagulation, Thrombin activity, medicine, Once daily, medicine.drug, Partial thromboplastin time |
| الوصف: | The coagulation-inhibiting effect of subcutaneously administered commercial and a low-molecular heparin was compared in healthy volunteers. Global clotting activity, measured as activated partial thromboplastin time as well as thrombin activity were inhibited almost equally by commercial and low-molecular heparin. Low-molecular heparin caused a ten-fold stronger inhibition of factor Xa. The effect on factor Xa increased nearly logarithmically with the injected dose. Half-life of heparin measured in terms of the inhibition of factor Xa was 5.5 hours for the low-molecular and 3.5 hours for the commercial preparation. These results indicate that low-molecular heparin has a high specificity in the inhibition of factor Xa. A lower dose of low-molecular heparin, administered once daily, may have an anti-thrombotic effect while reducing the risk of bleeding. |
| تدمد: | 1439-4413 0012-0472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fe729fb6aad9532dc42e455c7fdf8610 https://doi.org/10.1055/s-2008-1069304 |
| رقم الأكسشن: | edsair.doi...........fe729fb6aad9532dc42e455c7fdf8610 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394413 00120472 |
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